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GHK-Cu has been applied to osteoblast precursor cell cultures (e.g., MC3T3-E1 cells) to investigate its role in osteogenesis

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Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)