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A primary function of PARPs is the post-translational modification of proteins, via the covalent addition of ADP-ribose polymer(s) to various proteins—a process known as mono-ADP-ribosylation (MARylation) when a single unit of ADP-ribose is added or polyADP-ribosylation (PARylation) when multiple ADP-ribose units are added (30)

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Importantly, AOD-9604 does not bind to growth hormone receptors, which is why it lacks the glucose-elevating and IGF-1-stimulating effects of full-length growth hormone