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It is well documented that α-MSH and its receptors MC1-R, MITF, TRP-1, and TRP-2, and endogenous ligand agouti signaling protein (ASIP) are the key regulators of melanin pigment generation in hair.[9] PTP20, an α-MSH agonist, has been reported to enhance the expression of catalase and to decrease (by ~30%) the intracellular level of H 2 O 2 in both in vivo and in vitro studies.[10] Furthermore, PTP20 has shown to activate the melanogenesis process in vitro and ex vivo , which has shown to be correlated with elevated expression of MC1-R, TRP-1, and with the reduction in ASIP expression

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