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It is not clear whether the replacement of melanocytes of the basal cell layer of the oral epithelium lost to physiological processes of apoptosis or senescence, or to mechanical, thermal, or chemical injury is the result of cell division of ‘mature’ melanocytes in the basal cell layer of the oral epithelium which still retain their capacity of replication, or a result of migration from their local niche reservoirs of melanocyte stem/progenitor cells and their subsequent proliferation [6]

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𝘠𝘦𝘴, 𝘸𝘩𝘦𝘯 𝘱𝘶𝘳𝘤𝘩𝘢𝘴𝘪𝘯𝘨 𝘵𝘩𝘦 𝘤𝘰𝘶𝘳𝘴𝘦 𝘷𝘪𝘢 𝘰𝘶𝘳 𝘸𝘦𝘣𝘴𝘪𝘵𝘦, 𝘺𝘰𝘶 𝘸𝘪𝘭𝘭 𝘴𝘦𝘦 𝘢 ‘𝘗𝘢𝘺 𝘪𝘵 𝘔𝘰𝘯𝘵𝘩𝘭𝘺’ 𝘰𝘱𝘵𝘪𝘰𝘯 𝘢𝘧𝘵𝘦𝘳 𝘤𝘩𝘦𝘤𝘬𝘰𝘶𝘵