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Neuropathic pain is a prominent feature of this CIPN, occurring in 25–80% of cases (Rampen et al., 2013), characterized by shooting pain and severe cramps, due to dysfunction of all three major sensory nerve fibers (Aβ, Aδ, and C), as demonstrated in both clinical and animal models (Cata et al., 2007)

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It is thus likely that this is a major form of metal accumulation throughout the human life and that the ability of nano-sized crystals to generate reactive chemical species under irradiation with light may possibly be related to their activity as catalytic generators of free radicals when embedded into the living tissue