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Accordingly, CII (260–267) and CII’s proteolytic fragments were found to be the core of the immunodominant peptides [36,69], and arthritogenic, respectively, although less so than native CII [36]

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A clinical study reported in 2014, involving 11 patients with acute myeloid leukemia (AML) excluding acute promyelocytic leukemia (APL), i.e., non-APL AML, reported a limited benefit provided by adding pharmacological doses of vitamin C (1 g/day over 30 min after arsenic trioxide, 5 days a week for 5 weeks) to the standard arsenic trioxide regimen [49]