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OCR was recorded three times under basal conditions and three times after the addition of Mito Stress compounds (Mito Stress Test Kit, Agilent, Santa Clara, California, USA): oligomycin (oligo, 1 µM, adenosine triphosphate (ATP)-synthase inhibitor), fluorocarbonyl cyanide phenylhydrazone (FCCP, 0.5 µM, decoupler), and rotenone/antimycin A (rot/AA, 0.5 µM, complex 3/1 inhibitor), as shown in Figure 1

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GI symptoms often resolve within 4–8 weeks as the body adapts to tirzepatide dosing