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4.1.3 Drug loading strategies From the reference to tables (2–6), plant-based metallic NPs in this review utilize: 4.1.3.1 Crude extracts The majority of formulations comprise entire plant extracts that contain many phytochemical components, such as alkaloids, flavonoids, and tannins (from, for example, Solanum nigrum , Tephrosia tinctoria , and Eysenhardtia polystachya ) (248)

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This enzymatic action depletes the available intracellular pool of nicotinamide, directly limiting the synthesis of nicotinamide adenine dinucleotide (NAD+)