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Oxidative stress-related biomarker dysregulations in ASD Our meta-analysis revealed blood oxidative glutathione (GSSG), homocysteine, S -adenosylhomocysteine (SAH), copper, nitric oxide, and malondialdehyde (MDA) concentrations were significantly higher in ASD children than that of HC children, as showed in Table 1 and Figs

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One proposed mechanism involves modulation of neurotransmitter systems in the brain, particularly GABAergic, opioidergic, serotonergic, and dopaminergic pathways that are known to regulate sleep, arousal, mood, and stress responses