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The time it takes for vitamin B12 (cobalamin) treatment to produce noticeable effects varies considerably depending on the severity of deficiency, the route of administration, and individual patient factors

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This complex process means that conditions affecting the stomach or intestines can significantly impair B12 absorption, including pernicious anaemia, atrophic gastritis, previous gastric surgery, coeliac disease, Crohn's disease, and long-term use of certain medications (such as metformin, proton pump inhibitors, and H2 antagonists)