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Mechanistically, GPX4 inhibition in HK-2 cells triggers iron-dependent release of pro-necrotic mediators that promote fibroblast proliferation and myofibroblast differentiation, effects reversed by Lip-1 (189)

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Consistent with the finding that male ME/CFS T cells did not hyperproliferate and displayed relative insensitivity to ROS, we did not observe any reduction in T cell proliferation upon treatment with NAC, metformin, or liproxstatin-1 ( SI Appendix , Fig