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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice Nat Med 2017;23(1):107-113 doi:10.1038/nm.4236 (Animal study) Bischoff SC, Barbara G, Buurman W, et al

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In vivo studies showed that amatoxin actions and hepatotoxicity are enhanced by TNF-α, and animals that underwent pre-treatment with anti-TNF antibodies had less liver injury [30]